May 15.2024



Flavonoids, a class of plant chemicals widely found in nature and renowned for their outstanding biological activities such as antioxidation, anti-inflammation, anti-tumor, and cardiovascular protection, include Scutellaria baicalensis Georgi, also known as Chinese skullcap, an herb with a long history in Asian traditional medicine. Its root is rich in flavonoids, particularly Wogonin. This compound, derived from Scutellaria baicalensis, has garnered significant attention for its potential application in anti-aging supplements due to its remarkable anti-inflammatory, antioxidant, and chondroprotective properties. Wogonin presents an attractive option for formulations targeting age-related health concerns.


Reserchers from Northeast Ohio Medical University found that Wogonin exerts chondro- and cartilage protection by suppressing key molecular events involved in oxidative stress, inflammation, and matrix degradation in human OA chondrocytes and cartilage explants. The results also demonstrate that induction of low levels of ROS in OA chondrocytes by Wogonin leads to the modulation of the redox-mediated induction Nrf2/ARE pathways via activation of ROS/ERK/Nrf2/HO-1-SOD2-NQO1 signaling axis (Fig. 1). Additionally, researchers highlight the potential of redox modifiers as promising anti-inflammatory and chondroprotective agents. The study provides novel insights into the development of Nrf2 as a promising candidate for the development of novel therapies for the management of OA.


For businesses in the supplement industry, integrating Wogonin into anti-aging formulations presents an opportunity to develop innovative products that target key aspects of aging-related health issues. Through scientific research and validation, companies can harness the potential of Wogonin to enhance the efficacy and appeal of their anti-aging supplements, meeting the growing demand for natural and effective solutions in the wellness market.


Introducing Botanicure: Your Partner in Health and Longevity


Botanicure is a company at the forefront of the natural health movement. We specialize in the development and distribution of high-quality, science-backed supplements that cater to the needs of companies seeking to improve their products for health and longevity.


At Botanicure, we believe in the power of nature to provide solutions to modern health challenges. With Wogonin, we offer a natural and effective way to support metabolic health and promote longevity. Join us in our mission to enhance lives through the wisdom of botanical cures.





Khan NM, Haseeb A, Ansari MY, Devarapalli P, Haynie S, Haqqi TM. Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes. Free Radic Biol Med. 2017 May;106:288-301. doi: 10.1016/j.freeradbiomed.2017.02.041. Epub 2017 Feb 22. PMID: 28237856; PMCID: PMC5490997.

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