Research

Gingerenone A

In the pursuit of eternal youth, there is a growing demand in the market for efficient and safe anti-aging products. Botanicure has always been at the forefront of this trend, dedicated to providing consumers with natural anti-aging solutions derived from nature. Recently, a novel natural ingredient extracted from ginger, Gingerenone A, heralds a significant breakthrough in the field of anti-aging.

Obesity and its complications are among the major health issues in today's society. In this regard, scientific research has revealed that Gingerenone A exhibits remarkable bioactivity; it can inhibit fat formation and lipid accumulation. This finding reveals its enormous potential in the field of anti-obesity treatment. Experimental results demonstrate that GA reduces mouse fat mass consistent with in vitro data, regulates fatty acid metabolism by activating AMPK[1], thereby slowing diet-induced obesity (DIO). Additionally, GA also shows an inhibitory effect on adipose tissue inflammation (ATI), further proving its potential as a candidate anti-obesity drug.

As we age, our cells undergo gradual aging, which is the fundamental cause of many age-related diseases. Encouragingly, researchers have found that Gingerenone A not only performs excellently in anti-obesity but also holds significant potential in anti-aging effects. Through studies on WI-38 human fibroblast cells, researchers discovered that Gingerenone A can selectively eliminate senescent cells without affecting normal cells  [2]. This unique mechanism suggests its crucial role in improving or even reversing the cellular aging process.

*Senolytic activity of gingerenone A

Gingerenone A emerges as a promising natural senolytic compound with distinct advantages over the more extensively studied D+Q (Dasatinib and Quercetin) combination. Its anti-inflammatory properties also hint at broader therapeutic potential in age-related inflammatory conditions. Originating from ginger, this compound may also enjoy greater public acceptance and offer cost and sustainability benefits. While D+Q has shown positive results in certain clinical trials, Gingerenone A's natural origin, safety profile, and potential for broader clinical utility make it a star molecule in the quest for anti-aging solutions.

Botanicure firmly believes that nature-based and scientifically proven principles are at the core of our new product development. Although Gingerenone A has not yet been widely used in the market, its powerful potential efficacy fills us with anticipation for its future. We believe that with further research, Gingerenone A will soon become an essential player in helping people achieve a healthy and youthful life.

Botanicure – Derived from nature, granting you health and youthfulness.

Reference: 

[1] Moaddel R, Rossi M, Rodriguez S, Munk R, Khadeer M, Abdelmohsen K, Gorospe M, Ferrucci L. Identification of gingerenone A as a novel senolytic compound. PLoS One. 2022 Mar 29;17(3):e0266135. doi: 10.1371/journal.pone.0266135. PMID: 35349590; PMCID: PMC8963586.

[2] Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon JY, Yang S, Kim JK, Park JHY, Lee KW. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 Oct;61(10):10.1002/mnfr.201700139. doi: 10.1002/mnfr.201700139. Epub 2017 Jul 20. PMID: 28556482; PMCID: PMC5947313.